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15 February 1998 | Volume 128 Issue 4 | Pages 285-288
Background: Estrogen replacement therapy (ERT) in postmenopausal women decreases cardiac mortality and improves endothelial function. The endothelium regulates vascular tone and growth by releasing such factors as nitric oxide and endothelin-1.
Objective: To determine whether ERT alters the balance between the total oxidized products of nitric oxide and endothelin-1.
Design: Single-arm, before-after clinical trial.
Setting: Outpatient clinical research center of an academic medical center.
Patients: 15 postmenopausal women.
Intervention: Treatment with 17ß-estradiol for 6 months and a 10-day course of methoxyprogesterone every 3 months.
Measurements: Plasma nitric oxide and endothelin-1 levels were measured at baseline and after 6 months of ERT.
Results: The mean baseline nitric oxide level was 27.5 nmol/mL (range, 20.3 to 34.8 nmol/mL) and increased by a mean of 7.2 nmol/mL (range, 0.2 to 14.1 nmol/mL) (P = 0.04). The mean baseline plasma endothelin-1 level was 16.4 pg/mL (range, 12.0 to 20.8 pg/mL) and decreased by a mean of 3.9 pg/mL (range, 0.4 to 7.8 pg/mL) (P = 0.04). The mean baseline ratio of nitric oxide to endothelin-1 was 2.0 (range, 1.3 to 2.8) and increased by 1.2 (range, 0.1 to 2.2) (P = 0.03).
Conclusion: ERT results in an increased ratio of nitric oxide to endothelin-1. This may be one mechanism by which ERT provides cardiovascular benefit.
Author and Article Information
From the Mayo Clinic and Mayo Foundation, Rochester, Minnesota.
BRIEF COMMUNICATION
The Effect of Estrogen Replacement Therapy on Plasma Nitric Oxide and Endothelin-1 Levels in Postmenopausal Women
Grant Support: By grants HL07111-21D and HL51736 from the National Institutes of Health, the Miami Heart Research Institute, the Rappaport Program in Vascular Biology, and the Mayo Foundation.
Requests for Reprints: Amir Lerman, MD, Department of Internal Medicine and Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.
Current Author Addresses: Drs. Best, Berger, and Lerman: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.
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