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15 September 1997 | Volume 127 Issue 6 | Pages 450-453
Background: Noninvasive positive-pressure ventilation may benefit patients with amyotrophic lateral sclerosis and respiratory insufficiency.
Objective: To determine 1) whether patients tolerant of noninvasive positive-pressure ventilation have better survival than intolerant patients and 2) whether bulbar symptoms account for intolerance of noninvasive positive-pressure ventilation.
Design: Observational cohort study.
Setting: Tertiary care referral center.
Patients: 39 patients with amyotrophic lateral sclerosis who were treated with noninvasive positive-pressure ventilation.
Intervention: Noninvasive positive-pressure ventilation was started for patients with new orthopnea, new hypercapnia, or both. Patients were divided into two groups: those tolerant of and those intolerant of noninvasive positive-pressure ventilation.
Results: The risk for death from onset of respiratory insufficiency was higher for intolerant patients than for tolerant patients (relative risk, 3.1 [95% CI, 1.8 to 9.6]). Moderate or severe bulbar symptoms were more prevalent among intolerant patients than among tolerant patients (67% compared with 33%; P = 0.04).
Conclusions: Among patients with amyotrophic lateral sclerosis, those who are tolerant of noninvasive positive-pressure ventilation have better survival than do those who are intolerant. Bulbar symptoms partially account for intolerance of noninvasive positive-pressure ventilation.
Author and Article Information
From Wayne State University School of Medicine, Detroit, Michigan; and the Cleveland Clinic Foundation, Cleveland, Ohio.
BRIEF COMMUNICATION
Effect of Noninvasive Positive-Pressure Ventilation on Survival in Amyotrophic Lateral Sclerosis
Acknowledgment: The authors thank Dr. Gary T. Ferguson for his comments and extensive review of the manuscript.
Requests for Reprints: Loutfi Sami Aboussouan, MD, Division of Pulmonary and Critical Care Medicine, Wayne State University School of Medicine, Harper Hospital, 3-Hudson, 3990 John R, Detroit, MI 48201.
Current Author Addresses: Dr. Aboussouan: Division of Pulmonary and Critical Care Medicine, Wayne State University School of Medicine, Harper Hospital, 3-Hudson, 3990 John R, Detroit, MI 48201.
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