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1 November 1995 | Volume 123 Issue 9 | Pages 673-675
Objective: To describe the effects of menopause on resting metabolic rate, body composition, fat distribution, physical activity during leisure time, and fasting insulin levels.
Design: A longitudinal comparison of metabolic changes in women who experienced menopause with changes in age-matched women who did not experience menopause.
Setting: General clinical research center.
Patients: An initial cohort of 35 sedentary healthy premenopausal women (age range, 44 to 48 years). After 6 years of follow-up, 18 women had spontaneously stopped menstruating for at least 12 months and 17 women remained premenopausal. No women received hormone replacement therapy.
Results: Women who experienced menopause lost more fat-free mass than women who remained premenopausal (–3.0 ± 1.1 kg and –0.5 ± 0.5 kg, respectively), had greater decreases in resting metabolic rate (–103 ± 55 kcal/d and –8 ± 17 kcal/d) and physical activity during leisure time (–127 ± 79 kcal/d and 64 ± 60 kcal/d), and had greater increases in fat mass (2.5 ± 2 kg and 1.0 ± 1.5 kg), fasting insulin levels (11 ± 9 pmol/L and –2 ± 5 pmol/L), and waist-to-hip ratios (0.04 ± 0.01 and 0.01 ± 0.01) (P
Conclusions: Natural menopause is associated with reduced energy expenditure during rest and physical activity, an accelerated loss of fat-free mass, and increased central adiposity and fasting insulin levels. These changes may indicate a worsening cardiovascular and metabolic risk profile.
Author and Article Information
From the University of Maryland and Baltimore Veterans Affairs Medical Center, Baltimore, Maryland.
BRIEF COMMUNICATION
Editor's Note: Publication of this article has been rescinded. Please see the Notice of Retraction.
Changes in Energy Balance and Body Composition at Menopause: A Controlled Longitudinal Study
0.01 for all comparisons). Menopause did not affect energy intake, fasting glucose levels, or peak oxygen consumption.
Grant Support: In part by the following grants from the National Institute of Aging: grant AG-07857, a Research Career and Development Award (KO4-AG00564), a predoctoral training grant (T32-AG00219), and a Special Emphasis Research Career Award (KO1-AG-00657). The study was also supported by the University of Maryland Claude D. Pepper Older Americans Independence Center and GCRC (RR-109).
Requests for Reprints: Eric T. Poehlman, MD, Baltimore Veterans Affairs Medical Center, Geriatrics Service [18], 10 North Greene Street, Baltimore, MD 21201.
Current Author Addresses: Drs. Poehlman, Toth, and Gardner: Baltimore Veterans Affairs Medical Center, Geriatrics Service [18], 10 North Greene Street, Baltimore, MD 21201.
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