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15 August 1995 | Volume 123 Issue 4 | Pages 241-249
Objective: To investigate whether concurrent administration of misoprostol reduces the occurrence of serious upper gastrointestinal complications, such as perforation, gastric outlet obstruction, or bleeding, in patients with rheumatoid arthritis who are receiving nonsteroidal anti-inflammatory drugs (NSAIDs).
Design: 6-month randomized, double-blind, placebo-controlled trial.
Setting: 664 clinical practices of family medicine, internal medicine, or rheumatology in the United States and Canada.
Patients: 8843 men and women (mean age, 68 years) receiving continuous therapy with any of 10 specified NSAIDs for control of symptoms of rheumatoid arthritis. Patients were enrolled between July 1991 and August 1993.
Intervention: Patients were randomly assigned to receive 200 µg of misoprostol or placebo four times a day.
Measurements: Development of serious upper gastrointestinal complications detected by clinical symptoms or findings (not by scheduled endoscopy).
Results: Serious upper gastrointestinal complications were reduced by 40% (odds ratio, 0.598 [95% CI, 0.364 to 0.982; P = 0.049]) among patients receiving misoprostol (25 of 4404 patients) compared with those receiving placebo (42 of 4439 patients). During the first month, more patients receiving misoprostol (20%) than placebo (15%) withdrew from the study, primarily because of diarrhea and related problems (P < 0.001). Risk factors for serious upper gastrointestinal complications were increasing age, history of peptic ulcer or bleeding, and cardiovascular disease. Patients with all four risk factors would have a 9% risk for a major complication in 6 months.
Conclusions: In older patients with rheumatoid arthritis, misoprostol reduced serious NSAID-induced upper gastrointestinal complications by 40% compared with placebo.
Author and Article Information
From the University of Washington, Seattle, Washington. Baylor College of Medicine, Houston, Texas. University of Pennsylvania, Philadelphia, Pennsylvania. Quintiles Transnational Corporation, Research Triangle Park, North Carolina. G.D. Searle & Company, Skokie, Illinois.
ARTICLE
Misoprostol Reduces Serious Gastrointestinal Complications in Patients with Rheumatoid Arthritis Receiving Nonsteroidal Anti-Inflammatory Drugs
A Randomized, Double-Blind, Placebo-Controlled Trial
Requests for Reprints: G. Steven Geis, MD, 4901 Searle Parkway (A-3E), Skokie, IL 60077.
Acknowledgments: The authors thank Marie Griffin, MD, MPH, and Kenneth Brandt, MD, for their critical review of the data for patients who had suspected gastrointestinal events; William A.T. Archambault Jr., PhD, and John C. Alexander, MD, for their suggestions regarding the manuscript; and the 664 participating physicians. A list of the names and cities of these physicians can be obtained by contacting the author.
Grant Support: By a grant from G.D. Searle & Co.
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C. J. Hawkey, J. A. Karrasch, L. Szczepanski, D. G. Walker, A. Barkun, A. J. Swannell, N. D. Yeomans, and The Omeprazole versus Misoprostol for NSAID-Induce Omeprazole Compared with Misoprostol for Ulcers Associated with Nonsteroidal Antiinflammatory Drugs N. Engl. J. Med., March 12, 1998; 338(11): 727 - 734. [Abstract] [Full Text] [PDF]
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G. Singh, D. R. Ramey, D. Morfeld, H. Shi, H. T. Hatoum, and J. F. Fries Gastrointestinal Tract Complications of Nonsteroidal Anti-inflammatory Drug Treatment in Rheumatoid Arthritis: A Prospective Observational Cohort Study Arch Intern Med, July 22, 1996; 156(14): 1530 - 1536. [Abstract] [PDF]
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A. S. Taha, N. Hudson, C. J. Hawkey, A. J. Swannell, P. N. Trye, J. Cottrell, S. G. Mann, T. J. Simon, R. D. Sturrock, and R. I. Russell Famotidine for the Prevention of Gastric and Duodenal Ulcers Caused by Nonsteroidal Antiinflammatory Drugs N. Engl. J. Med., May 30, 1996; 334(22): 1435 - 1439. [Abstract] [Full Text] [PDF]
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What can be done about osteoarthritis? DTB, May 1, 1996; 34(5): 33 - 35. [Abstract] [Full Text] [PDF]
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