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1 June 1993 | Volume 118 Issue 11 | Pages 838-843
Objective: To estimate the effectiveness of ovarian cancer screening with CA 125 and transvaginal sonography.
Design: Decision analysis was used to examine the no-screen compared with the screen strategy.
Setting: Estimates of cancer incidence, survival, and life expectancy were derived from population-based data and clinical series.
Subjects: A cohort of 40-year-old women of all races and residing in the United States.
Interventions: A one-time screening intervention. The criterion standard for diagnosis of ovarian cancer was evaluation with exploratory laparotomy.
Main Outcome Measure: Average years of life expectancy gained by women in the screened group.
Results: Screening for ovarian cancer with a combination of CA 125 and transvaginal sonography increases the average life expectancy in the population by less than 1 day.
Conclusions: Given the limited effect on overall life expectancy, it is unlikely that mass screening for ovarian cancer with CA 125 and transvaginal sonography would be an effective health policy.
Author and Article Information
From the Medical College of Wisconsin, Milwaukee, Wisconsin; Duke University Medical Center, Durham, North Carolina; Henry Ford Hospital, Detroit, Michigan.
ARTICLE
The Effectiveness of Ovarian Cancer Screening: A Decision Analysis Model
Requests for Reprints: Marilyn M. Schapira, MD, Section of General Internal Medicine, 5000 W. National Avenue, Clement J. Zablocki Veterans Affairs Medical Center, 111-B, Milwaukee, WI 53295-1000.
Acknowledgments: The authors thank John Pauk, MD, MPH, for review of the manuscript.
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